Atomistic description of conformational changes in proteins from pico to millisecond timescales

Atomistic description of conformational changes in proteins from pico to millisecond timescales

Virtual screens and de-novo ligand design via free energy calculations

Virtual screens and de-novo ligand design via free energy calculations

Rational ligand design by modulation of protein dynamics

Rational ligand design by modulation of protein dynamics

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Research in the Michel lab is focussed on quantitative description of protein-ligand interactions. This is pursued through development of biomolecular simulation software and algorithms, and biophysical measurements to characterise the structure, dynamics and thermodynamics of protein-ligand interactions. 

Currently

Latest News

New academic year update

08 October 2024

The group welcomes new PhD students Benedict Tan and Roy (Haolin) Du. Benedict is working on a molecular glues design project, in collaboration with the Centre for Targeted Protein Degradation...

Congratulations to Finlay

19 June 2024

Congratulations to Finlay Clark (3rd year PhD student) who has been named the 2024 winner of the Charles Rupert McIntyre Prize ! You can read more about Finlay’s achievements here...

New year update

06 February 2024

New Year update It’s already February, meaning an update about the last few months is well overdue. Stephen Farr left us to relocate to Barcelona, where he is putting his...

Welcome to new group members

03 October 2023

W Welcome to new group members Chenfeng Zhang, Rory Portman and Jamie van de Grampel. Chenfeng joins us to pursue a PhD on the topic of protein allostery, Rory and...

Our research is supported by:

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Meet our group members