Atomistic description of conformational changes in proteins from pico to millisecond timescales
Virtual screens and de-novo ligand design via free energy calculations
Research in the Michel lab is focussed on quantitative description of protein-ligand interactions. This is pursued through development of biomolecular simulation software and algorithms, and biophysical measurements to characterise the structure, dynamics and thermodynamics of protein-ligand interactions.
Currently
Research Software Engineer opportunity:
''Supporting the OpenMM Community-led Development of Next-Generation Condensed Matter Modelling Software''
Latest News
Half year update
A lot has happened lately and I have been too busy to share news about the lab activities. Here is a summary of all the good things that happened since...
New preprint on ABFE methodologies
Congratulations to Finlay whose collaborative work with Graeme Robb (AstraZeneca) and Daniel Cole (Newcastle) is now available as a preprint on chemrxiv. Finlay's work ''Comparison of Receptor-Ligand Restraint Schemes for...
New PhD opportunity
We have a vacancy for a PhD studentship starting in Sep 2023. See https://www.julienmichel.net/lab/media/attachments/2022/12/18/phd-studentship-2023-204-modellingallostery.pdf
Meet our group members