Computational models of protein dynamics

Atomistic description of conformational changes in proteins from pico to millisecond timescales

Molecular simulations for ligand design

Virtual screens and de-novo ligand design via free energy calculations

Ensemble-based drug design

Rational ligand design by modulation of protein dynamics

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Research in the Michel lab is focussed on quantitative description of protein-ligand interactions. This is pursued through development of biomolecular simulation software and algorithms, and biophysical measurements to characterise the structure, dynamics and thermodynamics of protein-ligand interactions. 


Latest News

New group photo - November 2022

09 November 2022
New group photo - November 2022

A long overdue task done !   

Welcome to Steve

03 November 2022

Stephen Farr has just joined the group as a research software engineer. Steve completed a PhD in Physics at Cambridge with Prof. Rosana Collepardo and was most recently an application consultant...

Welcome to Álvaro

27 October 2022

Álvaro Serrano Morrás has joined the group at the beginning of the month for a 3 month visit. Álvaro is a PhD student at the University of Barcelona in the group...

Welcome to Audrius

26 September 2022

A warm welcome to Audrius Kalpokas who joined the lab earlier this month to pursue a PhD on protein FEP methodologies in collaboration with Cresset. Audrius previously completed a Masters...

Latest Tweets

I’m undecided. Will go for GödelNet.

RT @cressetgroup: Use the new ‘Very Quick’ FEP calculation method in Flare™ V6.1 to rank small molecule modifications.…

RT @philbiggin: Next up is Adele Hardie from Edinburgh Uni…. ⁦@MgmsUpdates⁩ #YMF2022
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Our research is supported by:

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Meet our group members

East Chem