Computational models of protein dynamics

Atomistic description of conformational changes in proteins from pico to millisecond timescales

Molecular simulations for ligand design

Virtual screens and de-novo ligand design via free energy calculations

Ensemble-based drug design

Rational ligand design by modulation of protein dynamics

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Research in the Michel lab is focussed on quantitative description of protein-ligand interactions. This is pursued through development of biomolecular simulation software and algorithms, and biophysical measurements to characterise the structure, dynamics and thermodynamics of protein-ligand interactions. 

Currently

Latest News

In-person event !

13 November 2021
In-person event !

After a long spell the group was able to meet in-person for a dinner to celebrate Sofia's PhD viva, and to welcome new group members Anna, Eva and Finlay. Group...

Congratulations Dr Bariami !

10 November 2021
Congratulations Dr Bariami !

Well done to Sofia Bariami for defending her PhD thesis with minor corrections on Nov 2nd ! Sofia has recently moved on to Cresset for an industrial postdoc position.   

Welcome to our new PhD students

07 September 2021

Welcome to Finlay Clark, Anna Herz and Evangelia Notari who joined the group to pursue PhD projects. Finlay and Anna are working on binding free energy calculation methods, whereas Eva...

Congrats to Adele

21 July 2021

Well done to 1st year PhD student Adele Hardie for winning a poster prize at the 2021 CCP5 Summer School. Adele is working on allosteric fragment-based drug design methodologies.  

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Our research is supported by:

funder-dpst
funder-epsrc
funder-erc
funder-evotec
funder-mariecurieactions
funder-newton
funder-nvidia
funder-royalsociety
funder-ucb
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Meet our group members

East Chem
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