Julien Michel Lab, Edinburgh Univeristy

Computational models of protein dynamics

Atomistic description of conformational changes in proteins from pico to millisecond timescales

Molecular simulations for ligand design

Virtual screens and de-novo ligand design via free energy calculations

Ensemble-based drug design

Rational ligand design by modulation of protein dynamics

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Research in the Michel lab is focussed on quantitative description of protein-ligand interactions. This is pursued through development of biomolecular simulation software and algorithms, and biophysical measurements to characterise the structure, dynamics and thermodynamics of protein-ligand interactions.

Currently

Latest News

Group updates

05 May 2025

Two group members recently moved on to other pastures. Congratulations to Finlay who passed his PhD viva last month (unfortunately we were all so distracted that we forgot to take...

Wellcome to Silvia

04 February 2025

The group is happy to host visiting PhD student Silvia Menin from the University of Padova. Silvia is working in the group of Prof. Stefano Moro in collaboration with...

Young Modellers Forum 2024

02 December 2024

Congratulations to Finlay Clark for winning a prize for his talk on ''Automated Adaptive Absolute Binding Free Energy Calculations'' at the 28th Young Modellers Forum meeting in Oxford, November 29th...

New academic year update

08 October 2024

The group welcomes new PhD students Benedict Tan and Roy (Haolin) Du. Benedict is working on a molecular glues design project, in collaboration with the Centre for Targeted Protein Degradation...

Our research is supported by:

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Meet our group members

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