Atomistic description of conformational changes in proteins from pico to millisecond timescales
Virtual screens and de-novo ligand design via free energy calculations
Research in the Michel lab is focussed on quantitative description of protein-ligand interactions. This is pursued through development of biomolecular simulation software and algorithms, and biophysical measurements to characterise the structure, dynamics and thermodynamics of protein-ligand interactions.
Currently
PhD studentship opportunity:
''A combined physics and data-driven methodology for the rational design of molecular glues''
PhD studentship opportunity:
''Multifidelity simulations for high-throughput generative protein engineering pipelines''
In collaboration with the Stracquadanio group, School of Biological Sciences
Latest News
Welcome to new group members
W Welcome to new group members Chenfeng Zhang, Rory Portman and Jamie van de Grampel. Chenfeng joins us to pursue a PhD on the topic of protein allostery, Rory and...
Half year update
A lot has happened lately and I have been too busy to share news about the lab activities. Here is a summary of all the good things that happened since...
New preprint on ABFE methodologies
Congratulations to Finlay whose collaborative work with Graeme Robb (AstraZeneca) and Daniel Cole (Newcastle) is now available as a preprint on chemrxiv. Finlay's work ''Comparison of Receptor-Ligand Restraint Schemes for...
New PhD opportunity
We have a vacancy for a PhD studentship starting in Sep 2023. See https://www.julienmichel.net/lab/media/attachments/2022/12/18/phd-studentship-2023-204-modellingallostery.pdf
Meet our group members