Julien Michel Lab, Edinburgh Univeristy

Computational models of protein dynamics

Atomistic description of conformational changes in proteins from pico to millisecond timescales

Molecular simulations for ligand design

Virtual screens and de-novo ligand design via free energy calculations

Ensemble-based drug design

Rational ligand design by modulation of protein dynamics

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Research in the Michel lab is focussed on quantitative description of protein-ligand interactions. This is pursued through development of biomolecular simulation software and algorithms, and biophysical measurements to characterise the structure, dynamics and thermodynamics of protein-ligand interactions.

Currently

Latest News

Young Modellers Forum 2024

02 December 2024

Congratulations to Finlay Clark for winning a prize for his talk on ''Automated Adaptive Absolute Binding Free Energy Calculations'' at the 28th Young Modellers Forum meeting in Oxford, November 29th...

New academic year update

08 October 2024

The group welcomes new PhD students Benedict Tan and Roy (Haolin) Du. Benedict is working on a molecular glues design project, in collaboration with the Centre for Targeted Protein Degradation...

Congratulations to Finlay

19 June 2024

Congratulations to Finlay Clark (3rd year PhD student) who has been named the 2024 winner of the Charles Rupert McIntyre Prize ! You can read more about Finlay’s achievements here...

New year update

06 February 2024

New Year update It’s already February, meaning an update about the last few months is well overdue. Stephen Farr left us to relocate to Barcelona, where he is putting his...

Our research is supported by:

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Meet our group members

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