Computational models of protein dynamics

Atomistic description of conformational changes in proteins from pico to millisecond timescales

Molecular simulations for ligand design

Virtual screens and de-novo ligand design via free energy calculations

Ensemble-based drug design

Rational ligand design by modulation of protein dynamics

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Research in the Michel lab is focussed on quantitative description of protein-ligand interactions. This is pursued through development of biomolecular simulation software and algorithms, and biophysical measurements to characterise the structure, dynamics and thermodynamics of protein-ligand interactions. 

Currently

Latest News

Ciao Stefano !

02 August 2018
Ciao Stefano !

We say goodbye to Stefano Bosisio who has taken up a data modeller position at Sainsburys bank.  As you can see below Stefano looks clearly happy about his transition to the...

Welcome Jonathan

12 July 2018

Welcome to Jonathan Richards who has taken up a short postdoc position to work on synthesis of Cyclophilin inhibitors. 

Goodbye Alessio

02 July 2018
Goodbye Alessio

A warm goodbye to Alessio De Simone who has taken a research scientist position at Sygnature Discovery.

New translational research grant

25 April 2018

Many thanks to InnovateUK for the award of a grant to support our translational research activities. 

Latest Tweets

Julien Michel
@hannahbruce Watch https://t.co/wupVfE3kkh and then get on with making reviewer 2 happy
Julien Michel
RT @protoms_mc: 🥳🥳🥳🥳🥳🥳🥳🥳🥳🥳 New ProtoMS release!! Now onto version 3.4 with lots of new functionality..... 🥳🥳🥳🥳🥳🥳🥳🥳🥳🥳 https://t.co/dcQj98SXv5
Julien Michel
RT @drugdesigndata: Heads-up: D3R Grand Challenge 4 #GC4 will open in early September! BACE 1 with 160 affinities and ~20 poses to predict…
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Our research is supported by:

funder-dpst
funder-epsrc
funder-erc
funder-evotec
funder-mariecurieactions
funder-newton
funder-nvidia
funder-royalsociety
funder-ucb
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Meet our group members

East Chem