Computational models of protein dynamics

Atomistic description of conformational changes in proteins from pico to millisecond timescales

Molecular simulations for ligand design

Virtual screens and de-novo ligand design via free energy calculations

Ensemble-based drug design

Rational ligand design by modulation of protein dynamics

1 2 3

Research in the Michel lab is focussed on quantitative description of protein-ligand interactions. This is pursued through development of biomolecular simulation software and algorithms, and biophysical measurements to characterise the structure, dynamics and thermodynamics of protein-ligand interactions. 

Latest News

New group members

20 September 2017

Welcome to new PhD students Michail Papadourakis and Marie Bluntzer, and undergraduate students Haofan Yang and Kirsten Ritchie ! 

Congratulations to Charis and Harris

14 July 2017

Congratulations to Charis and Harris for publishing Pushing The Limits Of Detection Of Weak Binding Using Fragment Based Drug Discovery: Identification Of New Cyclophilin Binders in the Journal of Molecular...

Welcome back Charis Georgiou!

01 March 2017
Welcome back Charis Georgiou!

Welcome back to Dr. Charis Georgiou who will be working in the lab on an exciting protein crystallography project.

2 new EPSRC grants awarded

22 February 2017

Many thanks to the EPSRC for awarding us two research grants (on the same day!).

Latest Tweets

Julien Michel
Visiting Gianni de Fabritis at UPF / @acellera in Barcelona. Looking forward to stimulating discussions on mol. sims driven drug discovery!
Julien Michel
@alessiociulli bringing VHL to the masses since 2009
Julien Michel
@davidlmobley @jchodera @ChemRxiv Nice ! Any particular reason why you went for @ChemRxiv instead of @biorxivpreprint ?
Follow Julien Michel on Twitter

Our research is supported by:

1 2 3 4 5 6 7 8 9

Meet our group members

East Chem