Computational models of protein dynamics

Atomistic description of conformational changes in proteins from pico to millisecond timescales

Molecular simulations for ligand design

Virtual screens and de-novo ligand design via free energy calculations

Ensemble-based drug design

Rational ligand design by modulation of protein dynamics

1 2 3

Research in the Michel lab is focussed on quantitative description of protein-ligand interactions. This is pursued through development of biomolecular simulation software and algorithms, and biophysical measurements to characterise the structure, dynamics and thermodynamics of protein-ligand interactions. 

Currently

PhD studentship opportunity

In chemical biology/molecular modelling for a collaborative project with the Hulme group at the University of Edinburgh.

Latest News

Welcome back Charis Georgiou!

01 March 2017
Welcome back Charis Georgiou!

Welcome back to Dr. Charis Georgiou who will be working in the lab on an exciting protein crystallography project.

2 new EPSRC grants awarded

22 February 2017

Many thanks to the EPSRC for awarding us two research grants (on the same day!).

PhD studentship opportunity

22 February 2017

There is a PhD studentship opportunity for a joint research project with the chemical biology lab of Dr Alison Hulme - Stapled by design: New peptide-based therapeutic leads targeting protein-protein...

Proof of concept grant awarded

18 January 2017

We thank the European Research Council for the award of a Proof of Concept grant.

Latest Tweets

Julien Michel
RT @zenbrainest: Major advance in GPCR field (Nature) Phase-plate cryo-EM structure of a class B GPCR–G-protein complex https://t.co/VhMIZ…
Julien Michel
Onwards to MSKCC to meet with @jchodera et al and discuss pipelines for biomolecular simulations https://t.co/yy06FnfQQ6
Julien Michel
RT @SoftwareSaved: Are you applying to a @EPSRC #RSE fellowship? @chryswoods has excellent advice for you: https://t.co/myNB1QhboC https://…
Follow Julien Michel on Twitter

Our research is supported by:

funder-dpst
funder-epsrc
funder-erc
funder-evotec
funder-mariecurieactions
funder-newton
funder-nvidia
funder-royalsociety
funder-ucb
1 2 3 4 5 6 7 8 9

Meet our group members

East Chem