Computational models of protein dynamics

Atomistic description of conformational changes in proteins from pico to millisecond timescales

Molecular simulations for ligand design

Virtual screens and de-novo ligand design via free energy calculations

Ensemble-based drug design

Rational ligand design by modulation of protein dynamics

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Research in the Michel lab is focussed on quantitative description of protein-ligand interactions. This is pursued through development of biomolecular simulation software and algorithms, and biophysical measurements to characterise the structure, dynamics and thermodynamics of protein-ligand interactions. 

Latest News

Congratulations to Charis and Harris

14 July 2017

Congratulations to Charis and Harris for publishing Pushing The Limits Of Detection Of Weak Binding Using Fragment Based Drug Discovery: Identification Of New Cyclophilin Binders in the Journal of Molecular...

Welcome back Charis Georgiou!

01 March 2017
Welcome back Charis Georgiou!

Welcome back to Dr. Charis Georgiou who will be working in the lab on an exciting protein crystallography project.

2 new EPSRC grants awarded

22 February 2017

Many thanks to the EPSRC for awarding us two research grants (on the same day!).

PhD studentship opportunity

22 February 2017

There is a PhD studentship opportunity for a joint research project with the chemical biology lab of Dr Alison Hulme - Stapled by design: New peptide-based therapeutic leads targeting protein-protein...

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Julien Michel
RT @ppxasjsm: Joshua Ho talking about software validation #Biophysics2017
Julien Michel
On my way to Leuven to talk about ensemble-based drug design at EJD-TCCM
Julien Michel
RT @EdinburghChem: Congratulations to @ProfArno who has been awarded an OBE in the Queen's Birthday Honours list - for services to Chemistr…
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